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KMID : 0616120180490020165
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Korean Journal of Pharmacognosy
2018 Volume.49 No. 2 p.165 ~ p.171
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Permeation Characteristics of Transdermal Preparations Containing Artemisiae Capillaris Herba in Franz Diffusion Cell
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Kim Eun-Nam
Park Kyo-Hyun
Kim Bae-Hwan
Jeong Gil-Saeng
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Abstract
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Artemisiae Capillaris Herba is a dried aerial part of Asteraceae capillaris Thunb.(Compositae), which has been used in Korean traditional medicine for the treatment of various diseases. It has a variety of pharmacological activities and has been evaluated for potential as an active ingredient in cosmeceutical products. In the cosmetics industry, animal experiments is besides the major concern of ethics, there are few more disadvantages of animal experimentation like demand of skilled manpower, time consuming protocols and high cost. Therefore, various alternatives to animal experiments have been proposed. The purpose of this study was to investigate the skin permeation characteristics of chlorogenic acid and dimethyleculetin, which are constituent of Artemisiae Capillaris Herba by using Franz diffusion cell. As a result, skin permeability was characterized by flux(penetration rates) and Kp(permeability coefficient) value, chlorogenic acid had lower flux and Kp than dimethylesculetin. According to the definitions of Marzulli, chlorogenic acid and dimethylesculetin would be classified as ‘Moderate’ and ‘Very fast’ respectively. In conclusion, skin permeation characteristics of chlorogenic acid and dimethylesculetin were confirmed through Franz diffusion cell, and suggests the direction of alternative method for skin permeation of natural compounds.
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KEYWORD
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Artemisiae Capillaris Herba, Franz diffusion cell, Hairless mouse full skin, Flux, Kp
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